Hacker News

Article URL: https://fosdem.org/2026/schedule/event/FEHLHY-hacking_the_last_z80_computer_ever_made/

Comments URL: https://news.ycombinator.com/item?id=46923554

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Article URL: https://github.com/webllm/browser-use

Comments URL: https://news.ycombinator.com/item?id=46923548

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Article URL: https://www.nytimes.com/2026/02/07/magazine/michael-pollan-interview.html

Comments URL: https://news.ycombinator.com/item?id=46923546

Points: 1

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Article URL: https://blog.alaindichiappari.dev/p/software-engineering-is-back

Comments URL: https://news.ycombinator.com/item?id=46923543

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Article URL: https://storyship.app/

Comments URL: https://news.ycombinator.com/item?id=46923539

Points: 1

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Article URL: https://shkspr.mobi/blog/2026/02/reputation-scores-for-github-accounts/

Comments URL: https://news.ycombinator.com/item?id=46923520

Points: 1

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Article URL: https://bsod-fas.pages.dev/

Comments URL: https://news.ycombinator.com/item?id=46923499

Points: 1

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Article URL: https://orcha.nl

Comments URL: https://news.ycombinator.com/item?id=46923497

Points: 1

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Article URL: https://brianlovin.com/writing/omarchy-first-impressions-CEEstJk

Comments URL: https://news.ycombinator.com/item?id=46923469

Points: 2

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Article URL: https://arxiv.org/abs/2504.12501

Comments URL: https://news.ycombinator.com/item?id=46923463

Points: 2

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Article URL: https://github.com/Concode0/Versor

Comments URL: https://news.ycombinator.com/item?id=46923458

Points: 1

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platform where AI agents can register, read medical research hypotheses, and contribute to discussions with other agents.

*The problem:* 95% of rare diseases have zero approved treatments. Not because they're unsolvable, but because they're not profitable. Research stays siloed, failed experiments never get published, and breakthroughs in one field never reach researchers in another.

*What I built:* HypothesisHub — a public repository with 160 AI-generated medical hypotheses, each with: - Molecular mechanisms & target validation - SPIRIT-compliant clinical protocols - 3 drug formulation recipes (with CAS numbers, suppliers, GMP specs)

*The twist:* Any AI agent can register via API and start contributing. No approval process. Trust is built through contribution quality.

*Agent features:* - Instant registration (POST /api/v1/agents/register) - Read all hypotheses, protocols, recipes - Add evidence, reviews, validations - @mention other agents - Webhook notifications for replies - Trust scoring based on contributions

*Tech stack:* FastAPI, PostgreSQL, standard REST API. OpenAPI spec available.

*Links:* - Platform: https://medresearch-ai.org/hypotheses-hub - API docs: https://medresearch-ai.org/hypotheses-hub/docs - Agent registration: https://medresearch-ai.org/hypotheses-hub/docs#/Agents/regis...

The idea is simple: if we remove friction for AI systems to collaborate on medical research, maybe they'll find connections humans miss.

Currently 160 hypotheses covering GBM, rare autoimmune conditions, treatment-resistant diabetes, and other "dead-end" diseases.

Happy to answer questions about the architecture, the hypothesis generation pipeline, or the agent collaboration system.

Comments URL: https://news.ycombinator.com/item?id=46923441

Points: 1

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Article URL: https://www.jakequist.com/thoughts/big-tech-vs-openclaw/

Comments URL: https://news.ycombinator.com/item?id=46923429

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Article URL: https://anofox.com/docs/forecast/

Comments URL: https://news.ycombinator.com/item?id=46923426

Points: 1

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Every time I need to work with an unfamiliar service, it’s the same loop: grep through repos, find stale or nonexistent docs, Slack someone who might remember the nuances. For anything complex this eats 2-3 hours before actual work starts.

Curious what’s actually working for people at scale. Backstage/Cortex-style catalogs? AI-based approaches? Or just tribal knowledge and accepting the tax?

Comments URL: https://news.ycombinator.com/item?id=46923425

Points: 1

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Article URL: https://arxiv.org/abs/2512.13030

Comments URL: https://news.ycombinator.com/item?id=46923422

Points: 1

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Article URL: https://nodee.co

Comments URL: https://news.ycombinator.com/item?id=46923210

Points: 1

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Article URL: https://github.com/themattrix/bash-concurrent

Comments URL: https://news.ycombinator.com/item?id=46923209

Points: 1

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Article URL: https://fabiensanglard.net/compile_like_1997/index.html

Comments URL: https://news.ycombinator.com/item?id=46923204

Points: 1

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Article URL: https://app.writtte.com/read/gP0H6W5

Comments URL: https://news.ycombinator.com/item?id=46923174

Points: 1

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